PATM consultation day

November 2015, second consultation day

I asked for the second telephone consultation today.
I briefly talked about the current situation.

After that, I heard an explanation of the three types of test results I received last time.

First, organic aciduria test results showed that arabinose was high.
This indicates that there are many bacteria in the intestine, such as Candida.
And that means that the intestinal environment is unconditioned.

Next, according to the results of environmental pollutant inspection, it was found that the numerical values of environmental pollutants were high.
This is a feature of “PATM”.

Urinary excretion of heavy metals revealed that arsenic, mercury, and thallium exceeded the standard values.
Even so, we can see that we have not reached the outlier.

Based on the results of the test, he improved the intestinal environment and prescribed supplements with antioxidant effects.

The supplement was prescribed alpha lipoic acid, natural gamma, ultraflora IB, NAC.

Medical costs

・Telephone consultation　$20 22
・Alpha lipoic acid supplements (pure)　$36 40
・Natural Gamma E Supplements (Allergy Research Group)　$48 53
・Ultra Flora IB supplements　(Metagenics)　$93 03
・NAC supplements (Allergy Research Group)　$36 40

Medical costs are shown in US dollars.

The following is the inspection result.

Organic aciduria test

Results of organic aciduria test.

the first page

This is the first page of the organic aciduria test results.

Organic Acid Testing-Profile Testing in Nutrition and Metabolism

Growth of microorganisms in the intestine

Yeast and fungal markers

1 Citramalic acid
2 5-hydroxymethyl-2-furoic
3 3-oxoglutarate
4 Furan-2.5-dicarboxylic acid
5 Furancarbonylglycine
6 Tartaric acid
7 Arabinose
8 Carboxycitric acid
9 Tricarballylic acid

Bacterial marker
10 Hippuric acid
11 2-hydroxyphenylacetic acid
12 4-hydroxybenzoic acid
13 4-hydroxyhippuric acid
14 DHPPA (good bacteria) 3,4-dihydroxyphenylpropionic acid

Clostridia marker
15 4-hydroxyphenylacetic acid
16 HPHPA 3-(3-hydroxyphenyl)-3-hydroxypropanoic acid
17 4-cresol
18 3-indole acetic acid

2nd page

Oxalic acid metabolite
19 Glyceric acid
20 Glycolic acid
21 Oxalic acid

Glycolytic circuit metabolism
22 Lactic acid
23 Pyruvate

Mitochondrial marker: Krebs cycle metabolites
24 Succinic acid
25 Fumaric acid
26 Malic acid
27 2-oxoglutarate
28 Aconitic acid
29 citric acid

Mitochondrial markers: amino acid metabolites
30 3-methyl glutaric acid
31 3-hydroxyglutaric acid
32 3-methylglutaconic acid

Neurotransmitter metabolites
Phenylalanine and tyrosine metabolites
33 Homovanillic acid (HVA)
(Dopamine)
34 Vanillyl mandelic acid (VMA)
(Norepinephrine, epinephrine)
35 HVA / VMA ratio
Tryptophan metabolite
36 5-hydroxyindole acetic acid (5-HIAA)
(Serotonin)
37 Quinolinic acid
38 Kynurenic acid
39 Quinolinic acid / 5-HIAA ratio

3nd page

Pyrimidine metabolites-folate metabolism
40 Uracil
41 Thymine

Ketone & fatty acid oxidation
42 3-hydroxyacetic acid
43 Acetoacetic acid
44 4-hydroxyacetic acid
45 Ethyl malon
46 Methylsuccinic acid
47 Adipic acid
48 Suberic acid
49 Sebacic acid

Nutrition marker
Vitamin B12
50 Methyl malonic acid ＊
Vitamin B6
51 Pyridoxic acid (B6)
Vitamin B5
52 Pantothenic acid (B5)
Vitamin B2 (lipoflavin)
53 Glutaric acid ＊
Vitamin C
54 Ascorbic acid
Vitamin Q10 (CoQ10)
55 3-hydroxy-3-methyl glutaric acid ＊
Glutathione precursors and chelating substances
56 N-acetyl-L-cysteine (NAC)
Biotin (vitamin H)
57 Methyl citric acid ＊

＊ high value for this marker indicates a vitamin deficiency.(High levels of metabolites appear as there are no essential cofactors for enzymatic reactions)

4nd page

Substances that are indicators of detoxification
Glutathione
58 Pyroglutamic acid ＊
59 2-hydroxyacetic acid ＊

Excess ammonia
60 Orotic acid

Aspartame / salicylic acid / enteric bacteria
61 2-hydroxyhippuric acid

＊ High levels of this marker suggest glutathione deficiency.

Amino acid metabolites
62 2-hydroxyisovaleric acid
63 2-oxoisovaleric acid
64 3-methyl-2-oxovaleric acid
65 2-hydroxyisocaproic acid
66 2-oxoisocaproic acid
67 2-oxo-4-methylbutyric acid
68 Mandelic acid
69 Phenyl lactic acid
70 Phenylpyruvic acid
71 Homogentisic acid
72 4-hydroxyphenyl lactic acid
73 N-acetyl asparagine
74 Malonic acid

Mineral metabolites
75 phosphoric acid

5nd page (description)

Index of water intake (content)
76 ＊Creatinine

＊Since urine samples collected have different body fluid volumes, the creatinine test is used to stabilize and adjust the number of metabolic markers.
Urinary creatinine levels also vary depending on how much urine is collected.
If the amount of creatinine in the sample is less than 20 mg / dL, the sample does not meet the test criteria and is not suitable for testing.
If you want to test with a creatinine value other than this standard value, please consult your doctor or staff.

Inspection format description

Standard values for organic acid tests are established using urine samples taken by groups of individuals without morbidity or mental illness from all age groups.
This range is determined by calculating the mean and standard deviation and is displayed as ± 25D of the mean.
The standard values are specified by age and sex, and consist of adult males (≧ 13 years old), adult females (≧ 13 years old), boys (<13 years old), and girls (<13 years old).
The new test format for organic acid test and microbial organic acid test result has two display types.
See example results below.

In the first example, when the numerical value is within the standard value (Normal Range), it is displayed as plus (+) or minus (-) 2 standard deviation value.

The second example is displayed when the number exceeds the standard upper limit.
In this case, the reference value range of the graph is narrowed and the abnormal value is displayed so that it can be seen at a glance.
The lower limit of the standard value is not displayed.

In both cases, the patient number is shown in the diamond box on the graph.
If the numerical value is within the standard value, it will be displayed with a black framed diamond, and if the value is high or low, it will be displayed with a red framed diamond.

Report within the standard value (example)

Report outside standard value (example)

6nd page

Neurotransmitter metabolism marker

The figure contains patient test results for neurotransmitter metabolites and shows their relationship to the major biochemical pathways within the axon terminals of neurons.
The effect of microbial byproducts that block the conversion of dopamine to norepinephrine has also been shown.

7nd page

Interpretation

1-8) High levels of yeast and fungal metabolites indicate that yeast and fungi are growing in the intestine.
Yeast / fungal levels will be suppressed by potent multi-strain probiotic supplements along with natural (vegetable) antifungal substances.

33) Substandard HVA levels may be due to decreased production of the neurotransmitter dopamine due to decreased intake of the amino acid precursors phenylalanine and tyrosine.
Homovanillic acid is a metabolite of the neurotransmitter dopamine. Taking phenylalanine and tyrosine supplements may be beneficial.
It may also be deficient in the factor enzymes magnesium, B6 (pyridoxine), and biopterin, in which case taking supplements will increase neurotransmitter levels.

34) Substandard VMA levels may be due to decreased production of the neurotransmitter norepinephrine and the hormone adrenaline due to decreased intake of the amino acid precursors phenylalanine and tyrosine.
Vanillyl mandelic acid (VMA) is a metabolite of norepinephrine and adrenaline.
Low VMA levels may also be due to inhibition by the Clostridial metabolites during conversion to dopamine norebinephrine.
Phenylalanine and tyrosine supplements are effective.
They may be deficient in the cofactor enzymes magnesium, B6 (pyridoxine) and biopterin, and may respond to these supplements.

36) Values below the standard value for 5-hydroxyindoleacetic acid (5HIAA) suggest that the production of the neurotransmitter serotonin is down.
This is because 5-hydroxyindoleacetic acid is a metabolite of serotonin.
This low value is also associated with depression.
Supplementing 50-300 mg / day of 5HTP (5-hydroxytryptophan), a precursor of serotonin, may be beneficial.
Tryptophan supplement itself produces quinolinic acid, a neurotoxic and inflammatory metabolite, but 5HTP is not metabolized to quinolinic acid.
Excessive tryptophan supplementation is said to be associated with eosinophilia myalgia syndrome.

51) If pyridoxic acid (B6) is below the standard, you may not be in good health due to insufficient B6 intake, malabsorption, or enterotoxemia.
Pyridoxic acid is the main metabolite of vitamin B6.
20-50 mg / day of vitamin B6 and multivitamins are recommended.

52) High levels of pantothenic acid indicate a high intake of vitamin B5.
Pantothenic acid is an essential vitamin B.
Higher numbers do not necessarily indicate a need to reduce pantothenic acid intake, as some people may need to consume more pantothenic acid.
54) Substandard levels of ascorbic acid (vitamin C) may be associated with suboptimal health conditions (such as underdose, malabsorption and enterotoxemia).
It is recommended to take 1000mg of vitamin C supplement daily in 2 to 3 divided doses.

Low levels of the following metabolites are not clinically significant:
Citramalic acid, 2-hydroxyphenylacetic acid, 4-hydroxyphenylacetic acid, 4-hydroxybenzene, 4-hydroxyhippuric acid, 3-indoleacetic acid, glycerin,Glucose, oxalate, lactic acid, pyruvic acid, 2-hydroxybutyric acid, fumaric acid, malic acid, aconitic acid, quinolinic acid, kynurenic acid, quinoline / 5-HIAA ratio,Thymine, ethylmalonic acid, methylsuccinic acid, adipic acid, suberic acid, glutaric acid, 3-hydroxy-3-methylglutanic acid, methylcitric acid, orotic acid

62-74) Low numbers of amino acid metabolites indicate the absence of genetic disorders in amino acid metabolism.
These markers are byproducts of deamination (the state of ammonia removed) and are elevated when the enzyme is poorly functioning.
Slight increases may be due to genetic mutations or heterozygous conditions and may be alleviated with dietary restrictions and supplements.
Low levels of amino acid metabolites are not associated with inadequate protein uptake and are not specific amino acid defects.

8nd page

U.S. Patent (US Patent) # 5,686,311-organic acid test, some metabolites of fungal organic acid test [arabinose, citramalic acid, tartaric acid, 3-oxoglutaric acid,
Carboxycitric acid, 3,4-dihydroxyphenylpropionic acid (DHPPA), 3- (3-hydroxyphenyl) -3-hydroxypropionic acid (HPHPA)
Responses to autism are covered by US Patent # 5,686,311 issued November 11, 1997.

Environmental pollutant inspection

the first page

Measuring substance result range Population ranking
Exposure to xylene
1 3-methyl hippuric acid
2 2-methyl hippuric acid

Exposure to toluene
3 Hippuric acid
4 ＊Benzoic acid ester
Benzoic acid is metabolized to hippuric acid, which can cause an increase in hippuric acid that is independent of toluene.

Exposure to benzene
5 t, t-muconic acid

Exposure to trimethylbenzene
6 3,4-dimethyl hippuric acid

Exposure to styrene
7 Mandelic acid
8 Phenylglyoxylic acid
9 Mandelic acid + phenylglyoxylic acid

Exposure to phthalic acid
10 Monoethyl phthalate
11 Phthalic acid
12 Quinolinic acid

Exposure to parapen
13 Para-hydroxybenzoic acid ester

* Reference date updated: January 2013.Reference range is gender specific and will be updated regularly.For children, the results will vary depending on age.

This test is not for diagnostic purposes.
It also does not replace the guidance and treatment of medical personnel.
The US Biotech Institute has developed this test to determine its performance and characteristics.
This test has not been evaluated by the FDA.
This test is not for measuring inborn errors of metabolism in the newborn and is based on stable renal function and normal renal clearance.
The substances to be measured on the panel are subject to change without notice.
** Reference value range is not adjusted by gender or age

2nd page

Basic condition (High / Low) -exposure to environmental pollutants
Environmental pollutants
The% value (weighted deviation) below indicates how far the measured value is from the normal value.
A value above 25 is considered high and below -25 is considered low.

3nd page

Basic condition (alphabetical order) -exposure to environmental pollutants
Environmental pollutants
The% value (weighted deviation) below indicates how far the measured value is from the normal value.
A value above 25 is considered high and below -25 is considered low.

4nd page

Subject information summary
Environmental pollutants
Nutritional support
The following supplements may help improve your biochemistry balance. Please consult your doctor.

5nd page

More information on nutrition
Environmental pollutants
Nutritional and herbal information is provided based on studies of biochemical imbalances.
Recommendations are provided based on test results.
Please consult your doctor for interpretation.

See detailed information on nutrients below.

Benzene’s toxicity can be exacerbated by phenol and hydroquinone, so alcohol, coffee, and tea containing them should be avoided.
Also, cigarette smoke, which contains both benzene and phenolic compounds, is highly carcinogenic.
Some pathogenic enterobacteria cause the body to convert certain amino acids (tyrosines) into phenolic compounds.
So if your benzene marker is elevated, you should also look at your gut health.

Adult:
Probiotics-twice a day
Glutathione-300 mg x 2 times a day
Alpha lipoic acid-100 mg x twice a day
Selenium-200 mg daily
Vitamin E-400 IU x twice a day (mixed tocopherol) ＊IU (International Unit)
Vitamin C-500 mg x twice a day
Glycine-500 mg x twice a day
After 4-6 weeks, amino acid complex containing glycine 5-10 g / day
Using a sauna and increasing your intake of electrolyzed water are also important

Child:
Probiotics-twice a day
Alpha lipoic acid-50 mg x twice a day
Vitamin E-200 IU x twice a day (mixed tocopherols)
Vitamin C-250 mg x twice a day
Glycine-250 mg x twice a day

6nd page

More information on nutrition
Environmental pollutants

Nutritional and herbal information is provided based on studies of biochemical imbalances.
Recommendations are provided based on test results.
Please consult your doctor for interpretation.

See detailed information on nutrients below.

Phthalic acid is a chemical contained in all plastics.
It can cause damage to the developing fetus and is also known as a potent endocrine disruptor.
Although difficult, in order to reduce the burden on the body, never microwave food or heat food in plastic containers.
Improving Phase I and Phase II detoxification is also important.

Adult:
5-10g wide range supplement containing amino acids-glycine
Broad spectrum antioxidants-2 times a day
Ingest a large amount of water (preferably electrolyte added)
Avoid salicylate
Vitamin E-400 IU x 2 times a day (mixed tocopherols)
Magnesium 200 mg daily
Zinc-25 mg / day

Child:
2g wide range supplement containing amino acids-glycine
Broad spectrum antioxidants-once a day
Ingest a large amount of water (preferably electrolyte added)
Avoid salicylates
Vitamin E-400 IU x once a day (mixed tocopherol)
Magnesium-125 mg daily
Zinc-15 mg daily

7nd page

More information on nutrition
Environmental pollutants

Nutritional and herbal information is provided based on studies of biochemical imbalances.
Recommendations are provided based on test results.
Please consult your doctor for interpretation.

See detailed information on nutrients below.

Trimethylbenzene is used as a raw material for paint thinners, perfumes and dyes, and is also used as an additive for automobile fuels.

Adult:
Glycine-500 mg x twice a day
Ingest a large amount of water (preferably electrolyte added)
Broad spectrum antioxidants-2 times a day

Child:
Glycine-250 mg x twice a day
Ingest a large amount of water (preferably electrolyte added)
Broad spectrum antioxidants-once a day

8nd page

Drug interactions
Environmental pollutants
The following drugs may aggravate items that are out of range (high or low)
The number in parentheses after the drug indicates the number of times a warning regarding a potential harmful substance appeared.

9nd page

Panel/Subset Report
Environmental pollutants

Car source
2-methylhippuric acid, 3-methylhippuric acid, mandelic acid, phenylglyoxylic acid, M+P, t,t-muconic acid

Paints and solvents
3-methyl hippuric acid, mandelic acid, phenylglyoxylic acid, M+P

Personal care product source
Phthalic acid, monoethyl phthalate, para-hydroxybenzoic acid, t,t-muconic acid

Phthalates
Phthalic acid, monoethyl phthalate, quinolinic acid

Plastic source
Phthalic acid, monoethyl phthalate, mandelic acid, phenylglyoxylic acid, M+P

10nd page

Panel/Subset Report
Environmental pollutants

Water source
t,t-muconic acid, mandelic acid, phenylglyoxylic acid, M+P, 2-methylhippuric acid, 3,4-dimethylhippuric acid

11nd page

Clinical correlation
Environmental pollutants

Here, the test results are “matched” with the clinical findings. The following items, categorized as “decreased,” “normal,” or “increased,” tend to characterize clinical findings.
Highlighted items are considered to “match” the features of the clinical finding.
The other items are considered to be components of clinical findings, if not “match”.

12nd page

Comparison improvement report
Environmental pollutants

If you have been re-examined, a comparison and improvement report from the previous inspection will be displayed here.

Urinary excretion heavy metal test

Harmful heavy metal
Numerical value,Standard range,Within standard value,high

Aluminum
Antimony
Arsenic
Barium
Beryllium
Bismuth
Cadmium
Cesium
Gadolinium
Lead
Mercury
Nickel
Palladium
Platinum
Tellurium
Thallium
Thorium
Tin
Tungsten
Uranium

Creatinine
Creatinine

Sample data
The determination result is corrected by the creatinine concentration, taking into consideration the fluctuation due to urine dilution.
It shows the reference range and the corresponding graph, and the value of the population of healthy subjects under the unloaded test.
Chelation substances may increase urinary excretion of metals/elements.